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Kalispell Regional Healthcare

Open to Enrollment Studies

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Cancer

To learn more or enroll in the following studies, contact Glacier View Research Institute-Cancer.

BREAST CANCER COLLABORATIVE REGISTRY
An investigator-initiated, multisite institutional, noninterventional trial sponsored by the University of Nebraska Medical Center. The registry is focused on the collection of detailed information of participants to help create a resource that will be helpful to researchers in future studies related to breast cancer. It is the hope that future research using information from this registry will lead to improved diagnosis, prevention and treatment of breast cancers.
Principal investigator: Melissa Hulvat, MD

INCYTE MOST REGISTRY
A prospective, longitudinal, noninterventional study of disease burden and treatment of patients with low-risk myelofibrosis or high-risk essential thrombocythemia (ET) or ET patients receiving ET-directed therapy.
Principal investigator: Elise Anderes, MD

MERCK KEYNOTE 407
MK-3475-407-00
A randomized, double-blind, phase III study of carboplatin-paclitaxel/nab-paclitaxel chemotherapy with or without pembrolizumab (MK-3475) in first line metastatic squamous non-small cell lung cancer subjects.
Principal investigator: Elise Anderes, MD

MIRACA REGISTRY
A registry of hematopoietic disease for evaluation and correlation with clinical outcomes.
Principal investigator: Peter Wagner, MD

MONTANA CANCER CONSORTIUM TRIALS
The Montana Cancer Consortium is a NCI Community Oncology Research Program (NCORP) that gives patients at Kalispell Regional Healthcare access to more than 80 clinical trials for various disease sites, including brain, breast, lung, gastrointestinal, genitourinary, gynecological, lymphomas, melanoma, multiple myeloma and neuroendocrine diseases. These trials are sponsored by cooperative groups in the U.S. (i.e., ALLIANCE, ECOG-ACRIN, NRG, SWOG) and the National Cancer Institute (NCI). This includes cancer prevention clinical trials and cancer care delivery research (CCDR). For more information on the current trials, visit mtcancer.org.

NOVARTIS CLEE011G2301 (EARLEE-1)
A phase III, multicenter, randomized, double-blind, placebo-controlled study to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, high-risk early breast cancer.
Principal investigator: Ryan Roop, MD

Cardiology

To learn more or enroll in the following studies, contact Glacier View Research Institute-Cardiology.

ADVENT-HF
A study to assess the effects of adaptive servo ventilation (ASV) on survival and frequency of cardiovascular hospital admissions in patients with heart failure and sleep apnea. ASV is a device that delivers positive pressure to the airway using a face mask and is approved for the treatment of sleep apnea. Indications are heart failure patients with obstructive or central sleep apnea. Patients will be screened for sleep apnea if they have heart failure as determined by echocardiography at screening. Patients cannot already be using CPAP.
Principal investigator: Anthony Dal Nogare, MD
Sponsor: Canadian Institute of Health Research
Contact: Pat Keane-Richmond, RN, CCRC, at (406) 752-7636 or pkeane@krmc.org

ARTESIA
A study for patients with implanted devices which may record episodes of atrial fibrillation with durations of six minutes to 24 hours. Patients will be randomized to ASA or apixaban, and monitored for two years.
Principal investigator: Eve Gillespie, MD
Sponsor: Hamilton Health Sciences
Contact: Pat Keane-Richmond, RN, CCRC, at (406) 752-7636 or pkeane@krmc.org

CLEAR
A lipid trial testing a novel oral agent for CV patients unable to tolerate statin doses to lower LDL. Once a day dosing, five-year study.
Principal investigator: Eve Gillespie, MD
Sponsor: Esperion
Contact: Pat Keane-Richmond, RN, CCRC, at (406) 752-7636 or pkeane@krmc.org, or Lucia Kufa, RC, at (406) 257-8992 ext. 2230 or lkufa@krmc.org

ONCOCYTE
A lung cancer screening registry using biomarker testing for newly diagnosed lung nodules.
Principal investigator: Katarina Egressy, MD
Sponsor: OncoCyte
Contact: Pat Keane-Richmond, RN, CCRC, at (406) 752-7636 or pkeane@krmc.org

PERSPECTIVE
A clinical trial to evaluate the effects of Entresto vs. valsartan on cognitive function in patients with chronic heart failure with a preserved ejection fraction (HFpEF).
Principal investigator: Eve Gillespie, MD
Sponsor: Novartis
Contact: Pat Keane-Richmond, RN, CCRC, at (406) 752-7636 or pkeane@krmc.org, or Lucia Kufa, RC, at (406) 257-8992 ext. 2230 or lkufa@krmc.org

PLEXA REGISTRY
To confirm the long-term safety and reliability of Biotronik's Plexa lead, as used in conjunction with a U.S. market released Biotronik implantable cardioverter defibrillator or cardiac resynchronization therapy defibrillator pulse generator. The evaluation of safety will be based on the analysis of Plexa lead failures contributing to loss of bradycardia pacing or shock therapy. Additionally, acute and chronic Plexa lead parameters will be evaluated.
Principal investigator: Matt Brunson, MD
Sponsor: Biotronik
Contact: Pat Keane-Richmond, RN, CCRC, at (406) 752-7636 or pkeane@krmc.org, or Lucia Kufa, RC, at (406) 257-8992 ext. 2230 or lkufa@krmc.org

Endocrinology

To learn more or enroll in the following studies, contact Glacier View Research Institute-Endocrinology.

BEST
A double-blind, placebo-controlled study to evaluate the effects of bexagliflozin on hemoglobin A1c in patients with Type 2 diabetes and increased risk of cardiovascular adverse events.
Principal investigator: Jose de Souza, MD

NN1250-4252
A trial comparing the efficacy and safety of insulin degludec and insulin glargine 300 units/mL in subjects with Type 2 diabetes mellitus inadequately treated with basal insulin and oral antidiabetic drugs.
Principal investigator: Jose de Souza, MD

PROMINENT
Pemafibrate to reduce cardiovascular outcomes by reducing triglycerides in patients with diabetes.
Principal investigator: Jose de Souza, MD

Rheumatology

To learn more or enroll in the following studies, contact Glacier View Research Institute-Rheumatology.

CREDO 2
A randomized, double-blind, parallel-group, placebo- and active-controlled, multicenter phase III study of the efficacy and safety of olokizumab in subjects with moderately to severely active rheumatoid arthritis inadequately controlled by methotrexate therapy.
Principal investigator: Roger Diegel, MD

CREDO 3
A randomized, double-blind, parallel-group, placebo-controlled, multicenter phase III study of the efficacy and safety of olokizumab in subjects with moderately to severely active rheumatoid arthritis inadequately controlled by tumor necrosis factor alpha inhibitor therapy.
Principal investigator: Roger Diegel, MD

LILLY RHBX
A 52-week multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of ixekizumab (LY2439821) in bDMARD-naive patients with nonradiographic axial spondyloarthritis.
Principal investigator: Roger Diegel, MD